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DeCS
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Descriptor English:
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Uroporphyrinogen Decarboxylase
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Descriptor Spanish:
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Uroporfirinógeno Descarboxilasa
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Descriptor Portuguese:
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Uroporfirinogênio Descarboxilase
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Synonyms English:
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Uroporphyrinogen Carboxy-Lyase
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Tree Number:
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D08.811.520.224.125.900
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Definition English:
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An enzyme that catalyzes the decarboxylation of UROPORPHYRINOGEN III to coproporphyrinogen III by the conversion of four acetate groups to four methyl groups. It is the fifth enzyme in the 8-enzyme biosynthetic pathway of HEME. Several forms of cutaneous PORPHYRIAS are results of this enzyme deficiency as in PORPHYRIA CUTANEA TARDA; and HEPATOERYTHROPOIETIC PORPHYRIA. |
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Indexing Annotation English:
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/defic permitted but consider also PORPHYRIA CUTANEA TARDA and HEPATOERYTHROPOIETIC PORPHYRIA
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History Note English:
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91(76); was see under CARBOXY-LYASES 1976-90
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Allowable Qualifiers English:
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Record Number:
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14977
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Unique Identifier:
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D014575
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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